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Glucose Responsive Hydrogel Networks Based on Protein Recognition
Author(s) -
Ehrick Jason D.,
Luckett Matthew R.,
Khatwani Santoshkumar,
Wei Yinan,
Deo Sapna K.,
Bachas Leonidas G.,
Daunert Sylvia
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800337
Subject(s) - self healing hydrogels , drug delivery , chemistry , nanotechnology , materials science , polymer chemistry
Abstract Stimuli‐responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose‐responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative “accordion”‐like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications.