Premium
Porous Biodegradable Scaffold: Predetermined Porosity by Dissolution of Poly(ester‐anhydride) Fibers from Polyester Matrix
Author(s) -
Rich Jaana,
Korhonen Harri,
Hakala Risto,
Korventausta Joni,
Elomaa Laura,
Seppälä Jukka
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800306
Subject(s) - porosity , dissolution , polyester , chemical engineering , materials science , caprolactone , fiber , leaching (pedology) , matrix (chemical analysis) , scaffold , composite material , polymer chemistry , polymer , copolymer , biomedical engineering , medicine , environmental science , soil science , engineering , soil water
A novel selective leaching method for the porogenization of the biodegradable scaffolds was developed. Continuous, predetermined pore structure was prepared by dissolving fast eroding poly( ε ‐caprolactone)‐based poly(ester‐anhydride) fibers from the photo‐crosslinked poly( ε ‐caprolactone) matrix. The porogen fibers dissolved in the phosphate buffer (pH 7.4, 37 °C) within a week, resulting in the porosity that replicated exactly the single fiber dimensions and the overall arrangement of the fibers. The amount of the porosity, estimated with micro‐CT, corresponded with the initial amount of the fibers. The potential to include bioactive agents in the porogen fibers was demonstrated with the bioactive glass.