Amphiphilic Multi‐Arm Block Copolymer Based on Hyperbranched Polyester, Poly( L ‐lactide) and Poly(ethylene glycol) as a Drug Delivery Carrier | Zendy

Prabaharan Mani | Zendy; Grailer Jamison J. | Zendy; Pilla Srikanth | Zendy; Steeber Douglas A. | Zendy; Gong Shaoqin | Zendy

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Amphiphilic Multi‐Arm Block Copolymer Based on Hyperbranched Polyester, Poly( L ‐lactide) and Poly(ethylene glycol) as a Drug Delivery Carrier

Author(s) -

Prabaharan Mani,

Grailer Jamison J.,

Pilla Srikanth,

Steeber Douglas A.,

Gong Shaoqin

Publication year - 2009

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.200800269

Subject(s) - copolymer , amphiphile , ethylene glycol , micelle , drug delivery , polyester , polymer chemistry , chemistry , drug carrier , lactide , materials science , organic chemistry , polymer , aqueous solution

A novel type of biodegradable/biocompatible amphiphilic hyperbranched copolymer (H40‐PLA‐ b ‐MPEG) was synthesized. Its micellar properties were studied by DLS, fluorescence spectroscopy and TEM. The drug release profile showed that the H40‐PLA‐ b ‐MPEG micelles provide an initial burst release, followed by a sustained release of the entrapped hydrophobic model drug over a period of 4 to 58 h. The copolymer degraded hydrolytically within 6 weeks under physiological conditions. The MTT assay showed no obvious cytotoxicity against a human endothelial cell line at a concentration range of 0–400 µg · mL −1 . These results indicate that the H40‐PLA‐ b ‐MPEG micelles have great potential as hydrophobic drug delivery carriers.

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