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Amphiphilic Multi‐Arm Block Copolymer Based on Hyperbranched Polyester, Poly( L ‐lactide) and Poly(ethylene glycol) as a Drug Delivery Carrier
Author(s) -
Prabaharan Mani,
Grailer Jamison J.,
Pilla Srikanth,
Steeber Douglas A.,
Gong Shaoqin
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800269
Subject(s) - copolymer , amphiphile , ethylene glycol , micelle , drug delivery , polyester , polymer chemistry , chemistry , drug carrier , lactide , materials science , organic chemistry , polymer , aqueous solution
A novel type of biodegradable/biocompatible amphiphilic hyperbranched copolymer (H40‐PLA‐ b ‐MPEG) was synthesized. Its micellar properties were studied by DLS, fluorescence spectroscopy and TEM. The drug release profile showed that the H40‐PLA‐ b ‐MPEG micelles provide an initial burst release, followed by a sustained release of the entrapped hydrophobic model drug over a period of 4 to 58 h. The copolymer degraded hydrolytically within 6 weeks under physiological conditions. The MTT assay showed no obvious cytotoxicity against a human endothelial cell line at a concentration range of 0–400 µg · mL −1 . These results indicate that the H40‐PLA‐ b ‐MPEG micelles have great potential as hydrophobic drug delivery carriers.