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Unprecedented, Low Cytotoxicity of Spongelike Calcium Phosphate/Poly(ethylene imine) Hydrogel Composites
Author(s) -
Shkilnyy Andriy,
Gräf Ralph,
Hiebl Bernhard,
Neffe Axel T.,
Friedrich Alwin,
Hartmann Jürgen,
Taubert Andreas
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800266
Subject(s) - self healing hydrogels , calcium , chemistry , cytotoxicity , chemical engineering , brushite , mineralization (soil science) , phosphate , biomineralization , polymer chemistry , materials science , organic chemistry , biochemistry , nitrogen , engineering , in vitro
Covalently crosslinked PEI hydrogels are efficient templates for calcium phosphate mineralization in SBF. In contrast to the PEI hydrogels, non‐crosslinked PEI does not lead to calcium phosphate nucleation and growth in SBF. The precipitate is a mixture of brushite and hydroxyapatite. The PEI/calcium phosphate composite material exhibits a sponge like morphology and a chemical composition that is interesting for implants. Cytotoxicity tests using Dictyostelium discoideum amoebae show that both the non‐mineralized and mineralized hydrogels have a very low cytotoxicity. This suggests that next generation PEI hydrogels, where also the degradation products are non‐toxic, could be interesting for biomedical applications.