PAMAM Dendrimers as Potential Agents against Fibrillation of  α ‐Synuclein, a Parkinson's Disease‐Related Protein | Zendy

Rekas Agata | Zendy; Lo Victor | Zendy; Gadd Gerry E. | Zendy; Cappai Roberto | Zendy; Yun Seok I. | Zendy

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PAMAM Dendrimers as Potential Agents against Fibrillation of α ‐Synuclein, a Parkinson's Disease‐Related Protein

Author(s) -

Rekas Agata,

Lo Victor,

Gadd Gerry E.,

Cappai Roberto,

Yun Seok I.

Publication year - 2009

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.200800242

Subject(s) - dendrimer , fibril , fibrillation , biophysics , chemistry , alpha synuclein , inhibitory postsynaptic potential , parkinson's disease , biochemistry , disease , neuroscience , biology , medicine , atrial fibrillation

The effect of PAMAM dendrimers (generations G3, G4 and G5) on the fibrillation of α ‐synuclein was examined by fluorescence and CD spectroscopy, TEM and SANS. PAMAM dendrimers inhibited fibrillation of α ‐synuclein and this effect increased both with generation number and PAMAM concentration. SANS showed structural changes in the formed aggregates of α ‐synuclein – from cylindrical to dense three‐dimensional ones – as the PAMAM concentration increased, on account of the inhibitory effect. PAMAM also effectively promoted the breaking down of pre‐existing fibrils of α ‐synuclein. In both processes – that is, inhibition and disassociation of fibrils – PAMAM redirected α ‐synuclein to an amorphous aggregation pathway.

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