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Ring‐Opening Polymerization of DD ‐Lactide Catalyzed by Novozyme 435
Author(s) -
Hans Marc,
Keul Helmut,
Moeller Martin
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800236
Subject(s) - polymerization , monomer , chemistry , catalysis , lactide , polymer chemistry , polymer , toluene , ring opening polymerization , organic chemistry
In contrast to LLA, DLA is converted in toluene solution under mild reaction conditions (50–70 °C) using Novozyme 435 (immobilized CALB) to form the corresponding polymer. The influence of several parameters, such as enzyme concentration, temperature and monomer concentration, on the polymerization rate and the monomer conversion was studied. In contrast to the Novozyme 435 catalyzed polymerization of ε ‐caprolactone, enzyme deactivation occurs. It is attributed to the deprivation of water from the enzyme. This work points out that by careful selection of the reaction conditions, it is possible to obtain poly( D ‐lactide) in reasonable molecular weights and in high yields using Novozyme 435 catalysis.