Premium
Electrospun Non‐Woven Nanofibrous Hybrid Mats Based on Chitosan and PLA for Wound‐Dressing Applications
Author(s) -
Ignatova Milena,
Manolova Nevena,
Markova Nadya,
Rashkov Iliya
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800189
Subject(s) - nanofiber , electrospinning , chitosan , polymer chemistry , chemical engineering , adhesion , wound dressing , solvent , chemistry , materials science , composite material , polymer , organic chemistry , engineering
Continuous defect‐free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one‐step electrospinning of Ch or QCh solutions mixed with poly[( L ‐lactide) ‐co‐ ( d,l ‐lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch‐ and QCh‐containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent‐cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus . The hybrid nanofibers are promising for wound‐healing applications.