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Polyelectrolyte Coated PLGA Nanoparticles: Templation and Release Behavior
Author(s) -
Zhou Jie,
Moya Sergio,
Ma Lie,
Gao Changyou,
Shen Jiacong
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800188
Subject(s) - plga , rhodamine 6g , zeta potential , nanoparticle , polyelectrolyte , carbodiimide , ethylene glycol , polymer chemistry , peg ratio , chemical engineering , surface modification , acrylic acid , materials science , chemistry , rhodamine , nanotechnology , organic chemistry , polymer , copolymer , physics , finance , quantum mechanics , molecule , engineering , economics , fluorescence
Poly[( D , L ‐lactide)‐ co ‐glycolide] nanoparticles coated with polyethyleneimine on their surface were prepared by an emulsification‐solvent evaporation method and subsequently surface modified by LBL assembly. The assembly of poly(acrylic acid) and polyethyleneimine on a planar substrate and on the PLGA nanoparticles was monitored by QCM‐D, ζ ‐potential, flow cytometry and TEM. Carboxylic and amino groups in the multilayers were crosslinked by carbodiimide condensation, which was also later used to graft poly(ethylene glycol) (PEG). Rhodamine 6G, 5(6)‐carboxyfluorescein and fluorescein were incorporated into the nanoparticles and their release profiles were recorded at 60 °C and at 37 °C for rhodamine 6G, for nanoparticles with a multilayer coating, and those that were crosslinked and grafted with PEG.