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Biodegradable Nanogels Prepared by Self‐Assembly of Poly( L‐ lactide)‐Grafted Dextran: Entrapment and Release of Proteins
Author(s) -
Nagahama Koji,
Ouchi Tatsuro,
Ohya Yuichi
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800175
Subject(s) - dextran , lysozyme , chemistry , nanogel , polymer chemistry , lactide , conjugate , swelling , copolymer , nanoparticle , chemical engineering , drug delivery , biophysics , polymer , organic chemistry , biochemistry , mathematical analysis , mathematics , engineering , biology
We showed previously that poly( L‐ lactide)‐grafted dextran could form biodegradable nanogels in water. In this paper, various properties of Dex ‐g‐ PLLA nanogels were compared with Dex‐Chol (dextran‐cholesterol conjugate) nanogels to investigate the effects of hydrophobic units. Dex ‐g‐ PLLA nanogels exhibited significantly lower CAC and higher colloidal stability, indicating a strong tendency to form nanogels. We prepared lysozyme‐loaded Dex ‐g‐ PLLA nanogels, and they exhibited a sustained release of lysozyme for 1 week without denaturation in PBS at 37 °C. The Dex ‐g‐ PLLA nanogels therefore have great potential as a delivery vehicle for therapeutic protein.