Premium
Synthesis of Collagen‐Like Sequential Polypeptides Containing O ‐Phospho‐ L ‐Hydroxyproline and Preparation of Electrospun Composite Fibers for Possible Dental Application
Author(s) -
Ohkawa Kousaku,
Hayashi Shinya,
Kameyama Naoto,
Yamamoto Hiroyuki,
Yamaguchi Mina,
Kimoto Shigenari,
Kurata Shigeaki,
Shinji Hisaaki
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800122
Subject(s) - hydroxyproline , gelatin , composite number , electrospinning , chemistry , phosphate , biocompatible material , mineralization (soil science) , biomaterial , calcium , extracellular matrix , polymer chemistry , chemical engineering , polymer , materials science , biochemistry , composite material , organic chemistry , biomedical engineering , medicine , engineering , nitrogen
A synthetic route is described for collagen‐like polypeptides constructed from O ‐phospho‐ L ‐hydroxyproline [Hyp(PO 3 H 2 )] residues. Using the synthetic polypeptides and a natural protein, gelatin, fine fibers and their network structures (ESNWs) were prepared via electrospinning. The composite ESNWs can induce the mineralization of calcium phosphate. The phosphoryl groups of the Hyp(PO 3 H 2 ) residues affect both the crystalline phase and amount of the calcium phosphate, depending on the chemical structure in the repeating sequence. The composite ESNWs can be developed as a biocompatible replacement of the extracellular matrix of hard tissues, and thus can be applied as dental materials for restoration of dental cavities or as a sealant for pits and fissures.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom