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Synthesis of Collagen‐Like Sequential Polypeptides Containing O ‐Phospho‐ L ‐Hydroxyproline and Preparation of Electrospun Composite Fibers for Possible Dental Application
Author(s) -
Ohkawa Kousaku,
Hayashi Shinya,
Kameyama Naoto,
Yamamoto Hiroyuki,
Yamaguchi Mina,
Kimoto Shigenari,
Kurata Shigeaki,
Shinji Hisaaki
Publication year - 2009
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800122
Subject(s) - hydroxyproline , gelatin , composite number , electrospinning , chemistry , phosphate , biocompatible material , mineralization (soil science) , biomaterial , calcium , extracellular matrix , polymer chemistry , chemical engineering , polymer , materials science , biochemistry , composite material , organic chemistry , biomedical engineering , medicine , engineering , nitrogen
A synthetic route is described for collagen‐like polypeptides constructed from O ‐phospho‐ L ‐hydroxyproline [Hyp(PO 3 H 2 )] residues. Using the synthetic polypeptides and a natural protein, gelatin, fine fibers and their network structures (ESNWs) were prepared via electrospinning. The composite ESNWs can induce the mineralization of calcium phosphate. The phosphoryl groups of the Hyp(PO 3 H 2 ) residues affect both the crystalline phase and amount of the calcium phosphate, depending on the chemical structure in the repeating sequence. The composite ESNWs can be developed as a biocompatible replacement of the extracellular matrix of hard tissues, and thus can be applied as dental materials for restoration of dental cavities or as a sealant for pits and fissures.