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Hydrogels for Potential Colon Drug Release by Thiol‐ene Conjugate Addition of a New Inulin Derivative
Author(s) -
Pitarresi Giovanna,
Tripodo Giuseppe,
Calabrese Rossella,
Craparo Emanuela Fabiola,
Licciardi Mariano,
Giammona Gaetano
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800043
Subject(s) - self healing hydrogels , chemistry , inulin , drug delivery , trypan blue , conjugate , methacrylate , polymer chemistry , controlled release , copolymer , polymer , biochemistry , in vitro , organic chemistry , nanotechnology , materials science , mathematical analysis , mathematics
Inulin was chosen as a starting polymer for biocompatible, pH‐sensitive and biodegradable hydrogels. Three INUDVSA‐TT hydrogels were obtained by crosslinking inulin derivatives with trimethylolpropane tris(3‐mercaptopropionate) under varying conditions. The resulting hydrogels were cell compatible, as demonstrated by MTS and trypan blue exclusion assays acting on Caco‐2 cells, and were biodegraded by inulinase and esterase, thus suggesting their use as colonic drug delivery systems. 2‐Methoxyestradiol, an anti‐cancer drug, was soaked in INUDVSA‐TT hydrogels and its in vitro release and apoptotic effect on Caco‐2 cells were evaluated.