Premium
Fibrinolytic Poly(dimethyl siloxane) Surfaces
Author(s) -
Chen Hong,
Wang Liang,
Zhang Yanxia,
Li Dan,
McClung W. Glenn,
Brook Michael A.,
Sheardown Heather,
Brash John L.
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800014
Subject(s) - chemistry , adsorption , contact angle , protein adsorption , fibrin , siloxane , x ray photoelectron spectroscopy , polymer chemistry , plasminogen activator , fibrinogen , lysine , nuclear chemistry , chemical engineering , polymer , organic chemistry , biochemistry , amino acid , medicine , engineering , immunology , biology
PDMS surfaces have been modified to confer both resistance to non‐specific protein adsorption and clot lyzing properties. The properties and chemical compositions of the surfaces have been investigated using water contact angle measurements, ATR FT‐IR spectroscopy, and XPS. The ability of the PEG component to suppress non‐specific protein adsorption was assessed by measurement of radiolabeled fibrinogen uptake from buffer. The adsorption of plasminogen from human plasma to the various surfaces was studied. In vitro experiments demonstrated that lysine‐immobilized surfaces with free ε ‐amino groups were able to dissolve fibrin clots, following exposure to plasma and tissue plasminogen activator.