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Novel Bone Substitute Composed of Oligomeric Proanthocyanidins‐Crosslinked Gelatin and Tricalcium Phosphate
Author(s) -
Chen KuoYu,
Shyu PeiChi,
Chen YuehSheng,
Yao ChunHsu
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200800007
Subject(s) - gelatin , swelling , chemistry , gtp' , composite number , phosphate , proanthocyanidin , reagent , degradation (telecommunications) , chemical engineering , biophysics , biochemistry , materials science , organic chemistry , polyphenol , composite material , biology , enzyme , telecommunications , antioxidant , computer science , engineering
A biodegradable GTP composite composed of OPCs crosslinked gelatin with tricalcium phosphate was prepared as a novel bone substitute. The effects of the degree of crosslinking on the swelling ratio, in vitro degradation rate, and morphology of the GTP composite are discussed. Adding OPCs to GP and GTP composites markedly reduced the degradation rate, indicating that OPCs are good crosslinking reagents for gelatin. Cytotoxic tests demonstrated that OPCs, gelatin and tricalcium phosphate released from GTP composite promoted the proliferation of MG‐63 cells. Results of this study suggest that the nontoxic GTP composite is suitable for use as a large defect bone substitute.