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Surface Functionalization of Porous Resorbable Scaffolds by Covalent Grafting
Author(s) -
Källrot Martina,
Edlund Ulrica,
Albertsson AnnChristine
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700329
Subject(s) - surface modification , grafting , covalent bond , porosity , polymer chemistry , chemistry , materials science , polymer science , chemical engineering , nanotechnology , composite material , polymer , organic chemistry , engineering
Resorbable porous scaffold discs and solid films were prepared from poly[(1,5‐dioxepan‐2‐one)‐ co ‐( L ‐lactide)] and poly[( ε ‐caprolactone)‐ co ‐( L ‐lactide)]. The surfaces of the scaffolds were functionalized to increase their hydrophilicity. A total of 90 samples were prepared to cover all important combinations of experimental and material factors, and all experimental data were fitted by a partial least square model. As a result of grafting, the porous discs and solid films exhibited a tremendous increase in wettability. The functionalized discs were hygroscopic so that water was instantly absorbed and thoroughly wet the substrates.