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Resorbable Scaffolds from Three Different Techniques: Electrospun Fabrics, Salt‐Leaching Porous Films, and Smooth Flat Surfaces
Author(s) -
FinneWistrand Anna,
Albertsson AnnChristine,
Kwon Oh Hyeong,
Kawazoe Naoki,
Chen Guoping,
Kang InnKyu,
Hasuda Hirokazu,
Gong Jiansheng,
Ito Yoshihiro
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700328
Subject(s) - nanofiber , electrospinning , leaching (pedology) , porosity , chemical engineering , materials science , solvent , scaffold , homogeneous , adhesion , composite material , polymer chemistry , chemistry , polymer , biomedical engineering , organic chemistry , medicine , environmental science , thermodynamics , physics , soil science , engineering , soil water
Nanofibrous scaffolds of poly[( L ‐lactide)‐ co ‐(1,5‐dioxepan‐2‐one)] generated by electrospinning have been compared with porous films obtained by solvent cast/salt leaching and homogeneous films. A comparison between the fibrous materials and the homogeneous solvent‐cast films revealed that the surface of the nanofibers was more hydrophobic and that the nanofibers were degraded more rapidly in the presence of proteinase. It was obvious that the strain‐to‐break was reduced by the nanofiber formation, it decreased from 370% to 130% independent of fiber diameter. These values were however considerably higher than the strain‐to‐break of the solvent‐cast/salt leaching scaffold. In addition, the nanofibrous material accelerated the adhesion and growth of the mesenchymal stem cell compared to the smooth material.