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Monodisperse Gelatin Microspheres as a Drug Delivery Vehicle: Release Profile and Effect of Crosslinking Density
Author(s) -
Choy Young Bin,
Cheng Felice,
Choi Hyungsoo,
Kim Kyekyoon Kevin
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700316
Subject(s) - glutaraldehyde , gelatin , dispersity , diffusion , chemical engineering , particle size , chemistry , particle (ecology) , kinetics , microparticle , drug delivery , degradation (telecommunications) , drug carrier , dosage form , polymer chemistry , chromatography , organic chemistry , telecommunications , physics , oceanography , quantum mechanics , computer science , engineering , thermodynamics , geology
Uniform gelatin microspheres (GMS) of a wet size of 100 µm in diameter were fabricated by the electric field assisted precision particle fabrication (E‐PPF) method and crosslinked with different glutaraldehyde (GA) concentrations to study the effect of the crosslinking density on drug release. The drug release profiles of the crosslinked GMS were studied along with the intraparticle drug distribution and the particle degradation characteristics. Due to the concentration gradient of GA along the diffusion path into the GMS, the crosslinking density is higher on the GMS surface, making it less susceptible to degradation. As a result, the GMS with higher GA concentrations (0.375–0.875%) exhibited a highly resistant surface toward enzymatic degradation. On the other hand, the amount of drug complexation at the surface decreases as the GA concentration increases, which can be attributed to the lowered basicity of gelatin caused by the increased crosslinking density. These factors collectively affect the drug release kinetics and give rise to similar release profiles for GMS above a GA concentration of 0.375%.