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In vivo Degradation and Histocompatibility of a Novel Class of Fluorescent Copolyanhydrides, Poly{[di( p ‐carboxyphenyl) succinate]‐ co ‐(sebacic anhydride)}
Author(s) -
Fan Jun,
Li Yan,
Jiang Hongliang,
Tang Guping,
Wang Liqun
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700280
Subject(s) - in vivo , chemistry , fluorescence , copolymer , in vitro , degradation (telecommunications) , sebacic acid , fluorescence microscope , polymer chemistry , polymer , biophysics , nuclear chemistry , organic chemistry , biochemistry , biology , telecommunications , physics , microbiology and biotechnology , quantum mechanics , computer science
In this work, the in vivo degradation and tissue compatibility of a novel class of inherently fluorescent copolyanhydrides, P(dCPS:SA), were investigated. It was found that the degradation of the copolyanhydrides increased with the increase of SA content in the copolymers. The in vivo degradation rate of the copolymers was slower than that studied in vitro . A surface erosion characteristic of the copolyanhydrides was revealed by SEM and fluorescent microscopy. Mild inflammatory reactions were observed on days 6 and 10 after implantation for all the studied copolymers. By the end of 30 d, there were almost no inflammation reactions taking place.
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