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Loading and in vitro Controlled Release of Indomethacin Using Amphiphilic Cholesteryl‐Bearing Carboxymethylcellulose Derivatives
Author(s) -
Yang Liqun,
Kuang Jianliang,
Wang Jun,
Li Zhiquan,
Zhang LiMing
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700186
Subject(s) - amphiphile , micelle , chemistry , drug delivery , in vitro , aqueous solution , copolymer , controlled release , chemical engineering , polymer chemistry , polymer , nuclear chemistry , biophysics , organic chemistry , biochemistry , engineering , biology
Amphiphilic CCMCs were synthesized under mild conditions and their chemical structures were characterized by FT‐IR and 1 H NMR spectroscopy. Fluorescence analysis showed that CCMCs could self‐associate to form polymeric micelles in aqueous solution. IND was encapsulated during the formation of CCMC micelles and its in vitro release properties were investigated. The loading capacity was more than 50% and the loaded IND was slowly and steadily released into the medium over a period of 8 h. The CCMC micelles showed pH‐responsive behavior during the drug‐loading and release processes. CCMC is promising as a potential delivery system for the controlled release of IND with a pH‐responsive property.