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Mucoadhesive and Elastic Films Based on Blends of Chitosan and Hydroxyethylcellulose
Author(s) -
Luo Kun,
Yin Jingbo,
Khutoryanskaya Olga V.,
Khutoryanskiy Vitaliy V.
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700185
Subject(s) - chitosan , materials science , adhesion , polymer blend , polymer , chemical engineering , polymer chemistry , buccal mucosa , composite material , copolymer , medicine , oral cavity , orthodontics , engineering
Mucoadhesive polymeric films have been prepared based on blends of chitosan and hydroxyethylcellulose. The blends have been characterized by IR spectroscopy, DSC, WAXD, TGA, SEM, and mechanical testing. It is demonstrated that the mechanical properties of chitosan are improved significantly upon blending with hydroxyethylcellulose. An increase in hydroxyethylcellulose content in the blends makes the materials more elastic. The thermal treatment of the blends at 100 °C leads to partial cross‐linking of the polymers and formation of water‐insoluble but swellable materials. The adhesion of the films towards porcine buccal mucosa decreases with increasing hydroxyethylcellulose content in the blends.