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Copolymers for Hepatocyte‐Specific Targeting Carrying Galactose and Hydrophobic Alkyl Groups
Author(s) -
Hiratsuka Takahiro,
Goto Mitsuaki,
Kondo Yoshiyuki,
Cho ChongSu,
Akaike Toshihiro
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700157
Subject(s) - copolymer , amphiphile , micelle , alkyl , chemistry , hepatocyte , polymer chemistry , hydrophobic effect , galactose , in vitro , biophysics , biochemistry , organic chemistry , aqueous solution , polymer , biology
Core‐forming hydrophobic alkyl groups were incorporated into amphiphilic PVLA to enhance the stability and inclusion ability of the homopolymeric micelles in water. The CAC and hepatocyte targeting in the synthesized P(VLA‐ co ‐VBH) were investigated in vitro . The CAC of the copolymers decreased and the stability of the copolymeric micelles increased with the incorporation of hydrophobic groups into the homopolymer. The galactose moieties in the copolymer could be recognized by the ASGP‐R of the hepatocytes through a receptor‐mediated mechanism. The copolymers efficiently delivered a water‐insoluble drug to the hepatocytes. Hence, they be used to deliver hydrophobic drugs to cure various liver diseases.