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Conjugation of Bioactive Groups to Poly(lactic acid) and Poly[(lactic acid)‐ co ‐(glycolic acid)] Films
Author(s) -
Prime Emma L.,
CooperWhite Justin J.,
Qiao Greg G.
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700153
Subject(s) - glycolic acid , plga , polymer , copolymer , polymer chemistry , monomer , lactic acid , chemistry , amine gas treating , adhesion , covalent bond , methacrylate , organic chemistry , biochemistry , in vitro , genetics , bacteria , biology
A novel PLA‐based polymer containing reactive pendent ketone or hydroxyl groups was synthesized by the copolymerization of L ‐lactide with ε ‐caprolactone‐based monomers. The polymer was activated with NPC, resulting in an amine‐reactive polymer which was then cast into thin polymeric films, either alone or as part of a blend with PLGA, before immersion into a solution of the cell adhesion peptide GRGDS in PBS buffer allowed for conjugation of GRGDS to the film surfaces. Subsequent 3T3 fibroblast cell adhesion studies demonstrated an increase in cellular adhesion and spreading over films cast from unmodified PLGA. Hence the new polymer can be used to obtain covalent linkage of amine‐containing molecules to polymer surfaces.