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Electrospun Chitosan‐Coated Fibers of Poly( L ‐lactide) and Poly( L ‐lactide)/Poly(ethylene glycol): Preparation and Characterization
Author(s) -
Spasova Maria,
Paneva Dilyana,
Manolova Nevena,
Radenkov Philip,
Rashkov Iliya
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700129
Subject(s) - chitosan , ethylene glycol , electrospinning , lactide , chemistry , dip coating , polymer chemistry , antibacterial activity , scanning electron microscope , coating , materials science , polymer , composite material , organic chemistry , copolymer , bacteria , biology , genetics
Fibrous poly( L ‐lactide) (PLLA) and bicomponent PLLA/poly(ethylene glycol) mats were prepared by electrospinning and then were coated with chitosan. The presence of chitosan coating was proved by scanning electron microscopy and by fluorescence microscopy. On contact with blood, the chitosan coating led to changes in erythrocyte shape and in their aggregation. The haemostatic activity of the mats increased with increasing chitosan content. Microbiological studies against Staphylococcus aureus revealed that the chitosan coating imparts antibacterial activity to the hybrid mats. The combined haemostatic and antibacterial activities render these novel materials suitable for wound‐healing applications.