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Unconventional Methyl Galactan Synthesized via the Thexyldimethylsilyl Intermediate: Preparation, Characterization, and Properties
Author(s) -
Koschella Andreas,
Inngjerdingen Kari,
Paulsen Berit S.,
Morris Gordon A.,
Harding Stephen E.,
Heinze Thomas
Publication year - 2008
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700120
Subject(s) - galactan , characterization (materials science) , chemistry , polymer science , materials science , nanotechnology , organic chemistry , polysaccharide
Reaction of a β ‐(1 → 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS‐derivatized methyl galactan contains differently methylated secondary hydroxyl groups. SEC and analytical ultracentrifugation showed a consistent decrease in the molecular weight after the consecutive reaction steps. Biological studies revealed that the methyl galactans are less active in complement fixation assays as compared with a 3‐ O ‐methyl galactan‐enriched polysaccharide fraction isolated from Acanthus ebracteatus .