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Polyelectrolyte Complexes Based on (Quaternized) Poly[(2‐dimethylamino)ethyl methacrylate]: Behavior in Contact with Blood
Author(s) -
Yancheva Elena,
Paneva Dilyana,
Danchev Dobri,
Mespouille Laetitia,
Dubois Philippe,
Manolova Nevena,
Rashkov Iliya
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700056
Subject(s) - polyelectrolyte , methacrylate , polymer chemistry , sulfonate , chemistry , copolymer , cationic polymerization , contact angle , polymer , sodium , materials science , organic chemistry , composite material
Polyelectrolyte complexes (PECs) between (quaternized) poly[2‐(dimethylamino)ethyl methacrylate] (PDMAEMA) and (crosslinked) N ‐carboxyethylchitosan (CECh) or poly(2‐acrylamido‐2‐methylpropane sodium sulfonate) (PAMPSNa) were prepared and characterized in terms of their stability, equilibrium water content, and surface morphology. The evaluation of the behavior of the studied PECs in contact with blood revealed that the (crosslinked) CECh/(quaternized) PDMAEMA complexes had lost the inherent PDMAEMA cytotoxicity but still preserved haemostatic activity. In contrast, the complex formation between (quaternized) PDMAEMA and PAMPSNa allowed the preparation of materials with improved blood compatibility.