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Novel Biodegradable Poly(1,8‐octanediol malate) for Annulus Fibrosus Regeneration
Author(s) -
Wan Yuqing,
Feng Gang,
Shen Francis H.,
Balian Gary,
Laurencin Cato T.,
Li Xudong
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700053
Subject(s) - biocompatibility , scaffold , polyester , tissue engineering , malic acid , chemistry , regeneration (biology) , ultimate tensile strength , biophysics , swelling , biomedical engineering , polymer chemistry , materials science , biochemistry , microbiology and biotechnology , composite material , organic chemistry , biology , medicine , citric acid
A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid‐based polyester poly(1,8‐octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased with the extension of the polymerization time, while the degradation rate decreased. Rat AF cells proliferated on the POM films and maintained their phenotype. The 3D scaffold also supported the growth of the AF cells, as confirmed by Safranin‐O and type II collagen staining. POM also demonstrated a good biocompatibility in an in vivo foreign body response assay, an important prerequisite for tissue engineering applications. This study suggests that elastic POM scaffold may be an ideal candidate for AF tissue engineering.