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In Situ Micro‐Sized Gel‐Forming Injectable Implant Using Biodegradable Amphiphilic Graft Copolymer
Author(s) -
Cho Kuk Young,
Lee Seongnam,
Park JungKi
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700045
Subject(s) - copolymer , amphiphile , polymer , biodegradable polymer , materials science , polymer chemistry , in situ , chemical engineering , viscosity , lactide , particle size , chemistry , organic chemistry , composite material , engineering
A synthesized graft polymer is used as a biodegradable polymer for an in situ gel‐forming injectable implant system. The amphiphilic character of the polymer in the graft structure lowered the viscosity of the polymer solution, which enabled easy injection. A micro‐sized gel can be obtained with this system, which has not been found for previous in situ gel‐forming systems with poly[( D , L ‐lactide)‐ co ‐glycolide] copolymer. In addition, a protein particle embedded gel exhibits good in vitro drug release performance as a result of the enhanced stability and shorter diffusion length.