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Chondroitin‐4‐Sulfate: A Bioactive Macromolecule to Foster Vascular Healing around Stent‐Grafts after Endovascular Aneurysm Repair
Author(s) -
Charbonneau Cindy,
Gautrot Julien E.,
Hébert MarieJosée,
Zhu X. X.,
Lerouge Sophie
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200700008
Subject(s) - chondroitin sulfate , stent , viability assay , adhesion , cell adhesion , chemistry , biomedical engineering , wound healing , apoptosis , glycosaminoglycan , surgery , medicine , biochemistry , organic chemistry
Deficient healing after endovascular aneurysm repair with a stent‐graft is thought to be related to pro‐apoptotic environment in abdominal aortic aneurysms and inertness of graft materials. We developed a bioactive coating containing chondroitin‐4‐sulfate and assessed its potential to improve cell adhesion, viability and resistance to apoptosis on PET surfaces. Coatings of collagen type I and CS were prepared and characterized by DMMB, FT‐IR, DSC, SEM and contact angle goniometry. Preliminary cell culture experiments with vascular smooth muscle cells showed increased adhesion and viability in serum‐free medium on CS‐coated surfaces compared to control PET films.