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A Micro/Nanoscale Surface Mechanical Study on Morpho‐Functional Changes in Multilineage‐Differentiated Human Mesenchymal Stem Cells
Author(s) -
Danti Serena,
D'Acunto Mario,
Trombi Luisa,
Berrettini Stefano,
Pietrabissa Andrea
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200600271
Subject(s) - mesenchymal stem cell , regenerative medicine , mesoderm , tissue engineering , morpho , nanotechnology , microbiology and biotechnology , materials science , biology , chemistry , stem cell , embryonic stem cell , biochemistry , genetics , gene
In recent years MSCs have become a very attractive tool in tissue engineering and regenerative medicine because of their ability to be committed along several lineages through chemical or physical stimuli. Nevertheless their therapeutic potential and plasticity are not yet totally understood. This report describes the use of AFM together with conventional microscopies to obtain mechanical information on cell surfaces and deposited extra cellular matrix molecules, after inducing the differentiation of human MSCs towards three typical mesoderm phenotypes. The aim is to correlate morphological, functional, and mechanical aspects of human MSCs to obtain a deeper understanding of their great potential.