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Oligosaccharide‐Modified Poly(propyleneimine) Dendrimers: Synthesis, Structure Determination, and Cu II Complexation
Author(s) -
Appelhans Dietmar,
Zhong Yong,
Komber Hartmut,
Friedel Peter,
Oertel Ulrich,
Scheler Ulrich,
Morgner Nina,
Kuckling Dirk,
Richter Sven,
Seidel Jürgen,
Brutschy Bernhard,
Voit Brigitte
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200600260
Subject(s) - dendrimer , chemistry , oligosaccharide , hydrodynamic radius , reductive amination , aqueous solution , amination , dynamic light scattering , end group , polymer chemistry , radius of gyration , proton nmr , stereochemistry , organic chemistry , nanotechnology , materials science , polymer , copolymer , nanoparticle , micelle , catalysis
The multiple application of reductive amination on primary amino groups of first and second generation poly(propyleneimine) dendrimers is used as a one‐pot approach to introduce twice the amount of the oligosaccharide units as surface groups, compared to initially present amino groups in the first and second generation dendrimers. This was proven by 1 H NMR, MALDI‐TOF‐MS, and LILBID‐MS analysis. The size of these dendrimers was determined by the hydrodynamic radius using pulsed field gradient NMR and dynamic light scattering. Molecular modeling confirmed the presence of dense‐shell dendrimers. These dendrimers exhibit a generation dependent Cu II /dendrimer ratio in an aqueous environment, highlighting these materials as possible metal‐carrier systems with a well‐defined oligosaccharide protection shell for application in a biological environment.