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Synthesis and Erosion Properties of PEG‐Containing Polyanhydrides
Author(s) -
Hou Sijian,
McCauley Laurie K.,
Ma Peter X.
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200600256
Subject(s) - sebacic acid , ethylene glycol , peg ratio , polymer , chemical engineering , chemistry , erosion , polymer chemistry , surface modification , materials science , organic chemistry , paleontology , finance , engineering , economics , biology
To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three‐component polyanhydrides of sebacic acid, 1,3‐bis( p ‐carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content. Correspondingly, the erosion rate increases with increasing PEG content, whereas it decreases with increasing specimen thickness. This indicates that the incorporation of poly(ethylene glycol) into traditional two‐component polyanhydrides retains their surface erosion properties while making the erosion rate tunable. The new polyanhydrides hold potential for drug delivery applications.