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Cell Migration Rate on Poly( ε ‐caprolactone)/Poly(ethylene glycol) Diblock Copolymers and Correlation with the Material Sliding Angle
Author(s) -
Hsu Shanhui,
Tang ChengMing,
Chiu JengJiann,
Liao TienChi,
Lin ChuChieh,
Iwata Hiroo
Publication year - 2007
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200600248
Subject(s) - copolymer , ethylene glycol , materials science , nanostructure , optical microscope , contact angle , chemical engineering , caprolactone , biomaterial , polymer chemistry , substrate (aquarium) , scanning electron microscope , composite material , polymer , nanotechnology , oceanography , geology , engineering
The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real‐time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.