Rapid and Efficient Enzyme Encapsulation in a Dendrimer Silica Nanocomposite | Zendy

Miller Scott A. | Zendy; Hong Edmund D. | Zendy; Wright David | Zendy

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Rapid and Efficient Enzyme Encapsulation in a Dendrimer Silica Nanocomposite

Author(s) -

Miller Scott A.,

Hong Edmund D.,

Wright David

Publication year - 2006

Publication title -

macromolecular bioscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.924

H-Index - 105

eISSN - 1616-5195

pISSN - 1616-5187

DOI - 10.1002/mabi.200600140

Subject(s) - mesoporous silica , horseradish peroxidase , nanocomposite , chemistry , dendrimer , chemical engineering , nanoparticle , glucose oxidase , silicon dioxide , immobilized enzyme , supramolecular chemistry , nanotechnology , mesoporous material , polymer chemistry , organic chemistry , materials science , enzyme , catalysis , molecule , engineering

Summary: We report the entrapment of horseradish peroxidase and quantitative encapsulation of glucose oxidase within silica nanoparticles by utilizing an amine‐terminated dendritic template. Our improved strategy employs a water‐soluble biomimetic template which is able to catalyze the condensation of Si(OH) 4 to silica nanoparticles while trapping an enzyme inside the mesoporous material. Kinetic analysis shows enzyme functionality to be mostly unchanged. Also, the role of p I and ionic strength within the encapsulation environment was found to strongly influence encapsulation. These results suggest that the electrostatic manipulation of a strong supramolecular silica‐precipitating complex of enzyme and dendrimer has the potential of adding a vast array of chemical and biological activity to hybrid materials.Enzyme immobilization within a silica nanocomposite.

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