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Reverse Thermal Gelation of Aliphatically Modified Biodegradable Triblock Copolymers
Author(s) -
Jo Seongbong,
Kim Jin,
Kim Sung Wan
Publication year - 2006
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200600127
Subject(s) - copolymer , polymer , biodegradable polymer , polymer chemistry , materials science , aqueous solution , chemical engineering , chemistry , organic chemistry , composite material , engineering
Summary: A simple aliphatic modification demonstrated how to turn a water‐soluble biodegradable triblock copolymer synthesized from PEG, L ‐lactide, and ε ‐caprolactone into a thermoreversible polymer of which aqueous solution underwent a sol‐to‐gel phase transition upon a mild temperature rise. Thermogelling behavior of the aliphatically modified polymer was dependent on the degree of aliphatic modification and polymer concentration. When the polymer solutions were subcutaneously injected into rats, immediate depot formation has been observed. The polymeric gel depots have lasted for two weeks in vivo. This aliphatically modified thermogelling polymer can find applications in drug delivery.Aliphatically modified biodegradable triblock copolymer and its thermal gelation.