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Improved Anti‐Inflammatory Properties for Naproxen with Cyclodextrin‐Grafted Polysaccharides
Author(s) -
Ramírez Héctor L.,
Cao Roberto,
Fragoso Alex,
TorresLabandeira Juan J.,
Dominguez Amalia,
Schacht Etienne H.,
Baños Maysa,
Villalonga Reynaldo
Publication year - 2006
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200600023
Subject(s) - naproxen , cyclodextrin , polysaccharide , chemistry , anti inflammatory , pharmacology , organic chemistry , medicine , alternative medicine , pathology
Summary: Mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with mono‐6‐butylenediamino‐6‐deoxy‐ β ‐cyclodextrin derivatives by reductive alkylation in the presence of sodium borohydride. The formation of supramolecular complexes between these polymers and Naproxen was confirmed by fluorescence spectroscopy. The solubility of the drug was 3.8–4.6 fold increased in the presence of the cyclodextrin‐grafted polysaccharides. The in vivo anti‐inflammatory property of Naproxen was 1.7 times higher after supramolecular association with β ‐cyclodextrin‐branched mannan.