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Novel Water‐Soluble Quaternary Piperazine Derivatives of Chitosan: Synthesis and Characterization
Author(s) -
Holappa Jukka,
Nevalainen Tapio,
Safin Rustam,
Soininen Pasi,
Asplund Tomas,
Luttikhedde Tiina,
Másson Már,
Järvinen Tomi
Publication year - 2006
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500202
Subject(s) - piperazine , heteronuclear single quantum coherence spectroscopy , moiety , chitosan , chemistry , carbon 13 nmr , proton nmr , ammonium , derivative (finance) , combinatorial chemistry , polymer chemistry , organic chemistry , nuclear magnetic resonance spectroscopy , financial economics , economics
Summary: Novel synthesis methods for the preparation of quaternary piperazine derivatives of chitosan were developed. Quaternary ammonium moiety can be selectively inserted into either one or both of the piperazine nitrogens, yielding structurally uniform chitosan derivative structures. Water‐soluble end products were thoroughly characterized with FT‐IR, 1 H NMR, 13 C NMR and 2D 1 H‐ 13 C HSQC NMR. The molecular weights of the end products were determined by GPC with triple detection.