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Preparation and Characterization of Novel Bone Scaffolds Based on Electrospun Polycaprolactone Fibers Filled with Nanoparticles
Author(s) -
Wutticharoenmongkol Patcharaporn,
Sanchavanakit Neeracha,
Pavasant Prasit,
Supaphol Pitt
Publication year - 2006
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500150
Subject(s) - polycaprolactone , electrospinning , ultimate tensile strength , composite number , nanoparticle , materials science , fiber , composite material , chemical engineering , chemistry , nanotechnology , polymer , engineering
Summary: Novel bone‐scaffolding materials were successfully fabricated by electrospinning from polycaprolactone (PCL) solutions containing nanoparticles of calcium carbonate (CaCO 3 ) or hydroxyapatite (HA). The diameters of the as‐spun fibers were found to increase with the addition and increasing amounts of the nanoparticles. The observed increase in the diameters of the as‐spun fibers with the addition and increasing amounts of the nanoparticulate fillers was responsible for the observed increase in the tensile strength of the obtained fiber mats. An increase in the concentration of the base PCL solution caused the average diameter of the as‐spun PCL/HA composite fibers to increase. Increasing applied electrical potential also resulted in an increase in the diameters of the obtained PCL/HA composite fibers. Lastly, indirect cytotoxicity evaluation of the electrospun mats of PCL, PCL/CaCO 3 , and PCL/HA fibers based on human osteoblasts (SaOS2) and mouse fibroblasts (L929) revealed that these as‐spun mats posed no threat to the cells, a result that implied their potential for utilization as bone‐scaffolding materials.