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Preparation and Interfacial Properties of a Novel Biodegradable Polymer Surfactant: Poly(ethylene oxide monooleate‐ block ‐ DL ‐lactide)
Author(s) -
Nishino Satoru,
Kitamura Yoshiro,
Kishida Akio,
Yoshizawa Hidekazu
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500124
Subject(s) - ethylene oxide , chemical engineering , materials science , polymer chemistry , contact angle , pulmonary surfactant , adsorption , lactide , oxide , polymer , aqueous solution , solvent , surface tension , surface energy , chemistry , copolymer , organic chemistry , composite material , physics , quantum mechanics , engineering
Abstract Summary: In this paper, we report a novel synthesis of poly(ethylene oxide monooleate‐ block ‐ DL ‐lactide) (MOPEO‐PLA) in the presence of stannous 2‐ethylhexanoate catalyst. By utilizing the surfactant property and the reactive double bond of the amphiphilic MOPEO‐PLA, various characteristics of PLA microspheres, such as surface and internal structure, surface morphology, release property, and so on, may potentially be controlled. MOPEO‐PLA was found to be hydrophobic enough to prevent loss by dissolution into aqueous solution, which is often a problem for MOPEO. Furthermore, the interfacial tension measurements of a MOPEO‐PLA/toluene/water system revealed that MOPEO‐PLA had a good surface activity almost equal to that of MOPEO. The MOPEO‐PLA/PLA blend films were prepared by solvent casting on a water layer. Contact‐angle measurements of MOPEO‐PLA/PLA blend films confirmed that the hydrophilic PEO segments were selectivity accumulated at the oil/water interface. Moreover, the surface free energy on the ‘water side’ of the MOPEO‐PLA/PLA blend films was increased because of the increase in polar components as a result of the ether bonds of the PEO segments.Schematic illustration of the adsorption property of a) MOPEO‐PLA with a high‐molecular‐weight PLA segment and b) MOPEO‐PLA with a low‐molecular‐weight PLA segment at an ethyl acetate/water interface.