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Ionically Crosslinked Alginate/Carboxymethyl Chitin Beads for Oral Delivery of Protein Drugs
Author(s) -
Shi XiaoWen,
Du YuMin,
Sun LiPing,
Yang JianHong,
Wang XiaoHui,
Su XueLi
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500063
Subject(s) - chemistry , bovine serum albumin , glucuronic acid , chitin , aqueous solution , nuclear chemistry , ferric , swelling , controlled release , chemical engineering , drug delivery , chitosan , chloride , bead , polymer chemistry , chromatography , polysaccharide , biochemistry , organic chemistry , materials science , engineering , composite material
Summary: Complex beads composed of alginate and carboxymethyl chitin (CMCT) were prepared by dropping aqueous alginate‐CMCT into an iron( III ) solution. The structure and morphology of the beads were characterized by IR spectroscopy and scanning electron microscopy (SEM). IR confirmed electrostatic interactions between iron( III ) and the carboxyl groups of alginate as well as CMCT, and the binding model was suggested as a three‐dimensional structure. SEM revealed that CMCT had a porous morphology while alginate and their complex beads had a core‐layer structure. The swelling behavior, encapsulation efficiency, and release behavior of bovine serum albumin (BSA) from the beads at different pHs were investigated. The BSA encapsulation efficiency was fairly high (>90%). It was found that CMCT disintegrated at pH 1.2 and alginate eroded at pH 7.4 while the complex beads could effectively retain BSA in acid (>85%) and reduce the BSA release at pH 7.4. The results suggested that the iron( III )‐alginate‐CMCT bead could be a suitable polymeric carrier for site‐specific protein drug delivery in the intestine.Iron( III )‐alginate‐CMCT beads crosslinked in ferric chloride.