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PLGA‐( L ‐Asp‐ alt ‐diol) x ‐PLGAs with Different Contents of Pendant Amino Groups: Synthesis and Characterization
Author(s) -
Zhao Jie,
Quan Daping,
Liao Kairong,
Wu Qing
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500043
Subject(s) - diol , copolymer , plga , polymer chemistry , chemistry , ethylene glycol , ring opening polymerization , glass transition , polymerization , stereochemistry , organic chemistry , polymer , biochemistry , in vitro
Summary: A series of novel biodegradable multi‐block copolymers PLGA‐( L ‐Asp‐ alt ‐diol) x ‐PLGA with pendant amino groups was synthesized by ring‐opening polymerization of D , L ‐lactide/glycolide( D,L‐ LA/GA) (75/25) using poly( N ‐Cbz‐ L ‐Asp‐ alt ‐diol)s as macroinitiator and stannous octoate as catalyst, in which the N ‐Cbz‐ L ‐Asp represents N ‐carbobenzyloxy‐ L ‐aspartic acid and diols are ethylene glycol, triethylene glycol, PEG200, and PEG600, respectively. Their structures and properties were characterized by FTIR, 1 H NMR, DSC, GPC, and elemental analysis (EA). The contents of the L ‐Asp unit in the copolymers were increased from 12.9 to 79.3 mmol · g −1 with decreasing the chain length of the diol, while the glass transition temperatures of the copolymers were decreased from 27.1 to 11.7 °C with increasing the chain length of the diol. Thus, the results in this study provide a way to prepare biomaterials with different L ‐Asp unit densities or different number of bioactive sites as well as different properties through adjusting the chain length of the diol.Synthesis of PLGA‐( N ‐Cbz‐ L ‐Asp‐ alt ‐diol) x ‐PLGA copolymers.