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Controlled Release of Goserelin from Microporous Polyglycolide and Polylactide
Author(s) -
Kovalchuk Andrey,
Fischer Wilfried,
Epple Matthias
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500033
Subject(s) - microporous material , chemistry , polymer science , chemical engineering , organic chemistry , engineering
Summary: Two microporous biodegradable polyesters, i.e., PGA and PDLLA, were obtained by solid‐state polymerization reaction from the sodium salts of the corresponding α ‐hydroxycarboxylic acids after washing out the by‐product sodium chloride. The polymers were shaped by cold uniaxial pressing, by hot uniaxial pressing, and by extrusion at elevated temperature. Due to the special microporosity of the polymers, the introduction of drugs is possible at moderate temperature. The release kinetics of the model drug Phe and of the anti‐tumor drug goserelin (an LH‐RH agonist) from compacted polymer samples were fast (approx. 2 d). The release kinetics of goserelin were corrected for the decomposition of the drug. External coatings with PDLLA or PLLA obtained by immersion in polymer solution strongly slowed down the release kinetics in the case of the PDLLA coating, giving an almost linear release during 100 d. A coating with PLLA was unsuitable to slow down the release kinetics.SEM picture of the surface of a PDLLA‐coated extruded sample (#9).