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Encapsulation and Controlled Release of a Hydrophobic Drug Using a Novel Nanoparticle‐Forming Hyperbranched Polyester
Author(s) -
Zou Jianhua,
Shi Wenfang,
Wang Jun,
Bo Jun
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200500015
Subject(s) - dynamic light scattering , polyester , amphiphile , succinic anhydride , nanoparticle , polymer chemistry , hydrodynamic radius , chemical engineering , hydrophobe , drug delivery , dendrimer , polymer , methacrylate , chemistry , materials science , organic chemistry , copolymer , nanotechnology , engineering
Summary: An amphiphilic, hyperbranched polymer suitable for use in controlled drug delivery is reported. This polymer was obtained by modification of the hyperbranched aliphatic polyester Boltorn™ H20 (H20) with succinic anhydride and then glycidyl methacrylate, and formed nanoparticles in aqueous solution. The critical association concentration was 7.4 × 10 −3 g · L −1 , as determined by fluorescence spectroscopy using pyrene as a molecular probe. A static/dynamic laser light scattering (LLS) study revealed that the average particle size was 39.4 nm with a low particle size distribution (PDI = 0.04), and that each particle was composed of about 350 amphiphilic molecules. Daidzein, a hydrophobic traditional Chinese medicine, was encapsulated during particle formation and the release properties were determined. The optimal feeding concentration of daidzein to hyperbranched polyester was 4.9 × 10 −5 g · mL −1 to 5.0 × 10 −3 g · mL −1 with a loading efficiency of 76.1%. In the presence of the enzyme Lipase PS, the drug loaded nanoparticles degraded in a random one‐by‐one manner and released the drug over a few days. This system is therefore a novel controlled drug release system based on nanoparticles formed of hyperbranched polyester.Encapsulation of daidzein by hyperbranched polyester particles.