Premium
Thermosensitive Biodegradable Polydepsipeptide
Author(s) -
Ohya Yuichi,
Toyohara Megumi,
Sasakawa Mitsuhiro,
Arimura Hidetoshi,
Ouchi Tatsuro
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400221
Subject(s) - isopropyl , isopropyl alcohol , polymer , chemistry , polymer chemistry , cloud point , degradation (telecommunications) , transmittance , aqueous solution , chemical engineering , materials science , organic chemistry , telecommunications , computer science , engineering , optoelectronics
Summary: A poly( N ‐isopropylacrylamide) (PNIPAAm)‐like biodegradable thermosensitive polydepsipeptide, poly[Glc‐Asn( N ‐isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc‐Asn]. Poly[Glc‐Asn( N ‐isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non‐toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 °C in water, make this polymer attractive for biomedical implant applications.The effect of the temperature on the light transmittance of a poly[Glc‐Asn( N ‐isopropyl)] solution.