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Microrobotics and MEMS‐Based Fabrication Techniques for Scaffold‐Based Tissue Engineering
Author(s) -
Zhang Han,
Hutmacher Dietmar W.,
Chollet Franck,
Poo Aun Neow,
Burdet Etienne
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400202
Subject(s) - scaffold , tissue engineering , interconnectivity , fabrication , nanotechnology , microelectromechanical systems , materials science , computer science , biomedical engineering , engineering , artificial intelligence , medicine , alternative medicine , pathology
Summary: Scaffold based tissue engineering strategies use cells, biomolecules and a scaffold to promote the repair and regeneration of tissues. Although scaffold‐based tissue engineering approaches are being actively developed, most are still experimental, and it is not yet clear what defines an ideal scaffold/cell construct. Solid free form fabrication (SFF) techniques can precisely control matrix architecture (size, shape, interconnectivity, branching, geometry and orientation). The SFF methods enable the fabrication of scaffolds with various designs and material compositions, thus providing a control of mechanical properties, biological effects and degradation kinetics. This paper reviews the application of micro‐robotics and MEMS‐based fabrication techniques for scaffold design and fabrication. It also presents a novel robotic technique to fabricate scaffold/cell constructs for tissue engineering by the assembly of microscopic building blocks.Scaffold design for a single step pop‐up assembly.