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Polymeric Micelles and Nanoparticles from Block and Statistical Poly(( RS )‐3,3‐dimethylmalic acid) Derivatives: Preparation and Characterization
Author(s) -
Ouhib Farid,
Randriamahefa Solo,
Wintgens Véronique,
Guérin Philippe,
Barbaud Christel
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400177
Subject(s) - micelle , amphiphile , copolymer , nanoparticle , transmission electron microscopy , polymer chemistry , materials science , chemistry , chemical engineering , polymer , characterization (materials science) , drug delivery , nanotechnology , organic chemistry , aqueous solution , engineering
Summary: Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring‐opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly(( RS )‐3,3‐dimethylmalic acid) and hydrophobic poly(hexyl ( RS )‐3,3‐dimethylmalate) segments. Micelles obtained from a well‐defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM).Electron transmission microphotography of nanoparticles of PDMMLAH 30 ‐ co ‐He 70 4 .