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Novel Acrylonitrile‐Based Copolymers Containing Phospholipid Moieties: Synthesis and Characterization
Author(s) -
Huang XiaoJun,
Xu ZhiKang,
Wan LingShu,
Wang ZhenGang,
Wang JianLi
Publication year - 2005
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400165
Subject(s) - copolymer , acrylonitrile , polymer chemistry , characterization (materials science) , phospholipid , chemistry , materials science , polymer science , polymer , organic chemistry , nanotechnology , membrane , biochemistry
Summary: Novel acrylonitrile‐based copolymers containing phospholipid moieties were synthesized by a three‐step process, which included the copolymerization of acrylonitrile and 2‐hydroxyethyl methacrylate (HEMA) in water and the reaction of the resulting poly[acrylonitrile‐ co ‐(2‐hydroxyethyl methacrylate)]s (PANCHEMA) with 2‐chloro‐2‐oxo‐1,3,2‐dioxaphospholane (COP) followed by the ring‐opening reaction of COP with trimethylamine. The chemical structure of PANCHEMA and the phospholipid‐containing acrylonitrile‐based copolymers (PLCANCP) was analyzed with FT‐IR spectroscopy, 1 H and 31 P NMR, and XPS. Surface properties of the studied copolymers were evaluated by the pure water contact angle, protein adsorption and platelets adhesion measurements. The water contact angle measured by sessile drop method decreased for the polymers in the following sequence: PAN, PANCHEMA, and PLCANCP. The adsorption amount of bovine serum albumin and the adhesive number of platelet followed the same decline sequence. These results demonstrate that the biocompatibility of the acrylonitrile‐based copolymer membranes could be improved efficiently by the introduction of phospholipid moieties.