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Controlling Degradation of Acid‐Hydrolyzable Pluronic Hydrogels by Physical Entrapment of Poly(lactic acid‐ co ‐glycolic acid) Microspheres
Author(s) -
Lee Jun Bae,
Chun Ki Woo,
Yoon Jun Jin,
Park Tae Gwan
Publication year - 2004
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400073
Subject(s) - poloxamer , glycolic acid , plga , self healing hydrogels , chemistry , copolymer , lactic acid , polymer chemistry , chemical engineering , polymer , organic chemistry , biochemistry , in vitro , biology , bacteria , engineering , genetics
Summary: Chemically crosslinked biodegradable hydrogels based on di‐acrylated Pluronic F‐127 tri‐block copolymer were prepared by a photopolymerization method. Poly(lactic acid‐ co ‐glycolic acid) (PLGA) microspheres were physically entrapped within the Pluronic hydrogel in order to modulate the local pH environment by acidic degradation by‐products of PLGA microspheres. The PLGA microspheres were slowly degraded to create an acidic microenvironment, which facilitated the cleavage of an acid‐labile ester‐linkage in the biodegradable Pluronic hydrogel network. The presence of PLGA microspheres accelerated the degradation of the Pluronic hydrogel and enhanced the protein release rate when protein was loaded in the hydrogel.SEM image of photo‐crosslinked Pluronic hydrogel entrapping PLGA microspheres.