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Formation and Degradation of Poly( D , L ‐lactide) Nanoparticles and Their Potential Application as Controllable Releasing Devices
Author(s) -
Zhao Yue,
Fu Jie,
Ng Dennis K. P.,
Wu Chi
Publication year - 2004
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400072
Subject(s) - nanoparticle , sodium dodecyl sulfate , dynamic light scattering , degradation (telecommunications) , hydrodynamic radius , cationic polymerization , chemistry , pulmonary surfactant , lactide , chemical engineering , polymer chemistry , materials science , polymer , nanotechnology , organic chemistry , copolymer , telecommunications , biochemistry , computer science , engineering
Summary: In the presence of surfactant, water‐insoluble poly( D , L ‐lactide) (PLA) was dispersed into narrowly distributed nanoparticles stable in water via microphase inversion. The structure and degradation of such formed nanoparticles were investigated by a combination of static and dynamic laser light scattering. Our results revealed that the degradation rate increased with the temperature and pH so that the degradation could be regulated from minutes to days. Using anionic sodium dodecyl sulfate (SDS) as stabilizer resulted in a slower degradation than using cationic hexadecyltrimethylammonium bromide (HTAB). The phthalocyanine chromophores (PC) could be encapsulated inside these PLA nanoparticles. The degradation of individual PLA nanoparticles led to a controllable releasing of PC. The absorption and fluorescence studies revealed a correlation between the degradation and the releasing of PC. Our results showed that a higher PC/PLA ratio could lead to a faster degradation.Hydrodynamic radius distributions f ( R h ) of PLA‐SDS and PLA‐HTAB nanoparticles.