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Temperature‐Sensitive Polyamidoamine Dendrimer/Poly( N ‐isopropylacrylamide) Hydrogels with Improved Responsive Properties
Author(s) -
Zhang JianTao,
Huang ShiWen,
Zhuo RenXi
Publication year - 2004
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200400003
Subject(s) - lower critical solution temperature , dendrimer , self healing hydrogels , poly(n isopropylacrylamide) , polymer chemistry , swelling , chemical engineering , drug delivery , chemistry , materials science , polymer , nanotechnology , copolymer , organic chemistry , engineering
Summary: Novel temperature‐sensitive poly( N ‐isopropylacrylamide)/amine‐terminated polyamidoamine dendrimer G6‐NH 2 hydrogels with fast responsive properties were synthesized by forming semi‐interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temperature above lower critical solution temperature (LCST), and exhibited higher equilibrium swelling ratio at room temperature. All these properties might be attributed to the incorporation of polyamidoamine dendrimer G6‐NH 2 , which forms water‐releasing channels and increases the hydrophilicity of PNIPA network. The novel hydrogels have potential applications in drug and gene delivery.Shrinking kinetics of homogeneous PNIPA hydrogel (H0) and novel PAMAM dendrimer G6‐NH 2 ‐containing hydrogels (H10, H20 and H30).