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Biodegradable Phosphorylcholine Polymer Hydrogels Cross‐Linked with Vinyl‐Functionalized Polyphosphate
Author(s) -
Iwasaki Yasuhiko,
Komatsu Shinpei,
Narita Tadashi,
Akiyoshi Kazunari,
Ishihara Kazuhiko
Publication year - 2003
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200390031
Subject(s) - self healing hydrogels , phosphorylcholine , polymer chemistry , polymerization , methacrylate , biocompatibility , polyphosphate , polymer , chemistry , radical polymerization , ring opening polymerization , materials science , organic chemistry , phosphate , biochemistry
A vinyl‐functionalized polyphosphate (PIOP) was synthesized by ring‐opening polymerization of 2‐isopropyl‐2‐oxo‐1,3,2‐dioxaphospholane and 2‐(2‐oxo‐1,3,2‐dioxaphosphoroyloxyethyl methacrylate) with triisobutylaluminum as an initiator. The number‐averaged molecular weight of the PIOP was 1.2 × 10 4 . The average number of vinyl groups in the PIOP is 2.20. Transparent hydrogels were prepared by the radical polymerization of 2‐methacryroyloxyethyl phosphorylcholine with PIOP as a cross‐linking reagent. These hydrogels may have many applications in the biomedical field because of their biodegradability and biocompatibility.Synthetic route of PIOP.