Premium
Chemoenzymatic Synthesis of Fucose‐ or Rhamnose‐Branched Polymer
Author(s) -
Raku Takao,
Tokiwa Yutaka
Publication year - 2003
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200390019
Subject(s) - chemistry , rhamnose , fucose , bacillus subtilis , organic chemistry , lipase , adipate , streptomyces griseus , vinyl acetate , polysaccharide , biochemistry , polymer , polymer chemistry , enzyme , copolymer , streptomyces , galactose , bacteria , biology , genetics
6‐Deoxy sugars having only secondary alcohols, namely, D ‐fucose, L ‐fucose, and L ‐rhamnose, were regioselectively esterified with divinyl adipate by enzymes. The compounds 2‐ O ‐vinyl adipolyl D ‐fucose and 2‐ O ‐vinyl adipolyl L ‐fucose were effectively produced in dimethylformamide by protease from Bacillus subtilis and Streptomyces griseus . Furthermore, 4‐ O ‐vinyl adipolyl L ‐rhamnose was effectively produced in pyridine by lipase from Pseudomonas sp. Each polymerizable sugar ester was polymerized by 1,1′‐azoisobutyronitrile to give polymers having a number average molecular weight of 5 000–14 000.Part of the chemoenzymatic synthesis of poly(6‐deoxy sugars).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom